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I'm no film connoisseur, but I
am a scientist and physician. Well, almost a physician. So it is from a biomedical perspective that I present my review of
I am Legend, starring Will Smith. This is the first film I have seen on opening weekend in as long as I can remember, and the first I've seen in a theater since
Arctic Tale. This article won't be a true
spoiler, but I will address several critical plot elements.
Stop reading if you don't want to ruin the surprises. First, it was nice to see the movie without knowing any of the story. (Will Smith got me in the theater.) Other reviews point out Smith's excellent acting, the weak CGI monsters and how much the story strays from the original novel by
Richard Matheson. And
Popular Mechanics assesses the verity of the 'junk science' built into the plot. I take a broader view. In sum, I was pleasantly surprised that not only was science important to this film, but it was the co-star. Enough with the preamble! Here's the review:
How many times have you seen a cocky scientist on TV extolling the unlimited cures science has to offer society? If you lived in California a few years ago, you probably met professor Irv Weissman and others promising that stem cells will cure diseases. (They were actually just hinting at it, but does that really matter now that CA is well on its way to funding $3 billion of stem cell science?)
I am Legend opens with a smug blond scientist admitting on local TV that yes, she
has cured cancer.
Note #1: Scientists, if you want to get visibility for science, you need to get on the local news! Evidently, this scientist has built a virus that prevents either tumorgenesis or malignancy. Fortunately, the film did not get into that detail, because I would have something significant to critique! What is notable is that the plot plays on the public's lingering fear of gene therapy. And of course, the worst nightmare comes true. The virus mutates into a lethal strain that results in symptoms part rabies, part ebola, part bird flu. The virus first requires physical contact for transmission, but soon aerosolizes and crosses species boundaries. I am skeptical that viral evolution could actually occur as quickly as in the film, but perhaps such a trait is what enabled one virus to cure every type of cancer in the first place.
Speaking of curing cancer, our mad scientist (who had a vaguely European accent), indicated that of 10,009 clinical trials, 10,009 people were cancer free. This is likely a consistency flaw instigated by the script writers, since later, Will Smith's character tests his "compound 6" and calls one experiment a clinical trial.
Note #2: A clinical trial includes hundreds, if not thousands of patients. This was a little mistake, but could misrepresent the process of evaluating safety and efficacy to the millions of people in the theater this weekend. By the way, this flaw was my infectious disease researcher wife's biggest beef with the film.
Speaking of infectious disease, we need to talk about immunity. If 1% or the world's population was immune to the film's virus, Manhattan should have been left with 15,000 people. It took 70 minutes or so for an explanation of why Will Smith's character was the only human remaining. It turns out that 30% of those who survived turned into zombies. These (poorly animated) zombies ended up killing the rest of the people. How likely is it that a virus could cause a devolution (or evolution) of humans into zombies?
Greg Bear offers a pretty believable mechanism in
Darwin's Radio. If this little viral beastie was a certain type of retrovirus, aggressive zombies
could be the next step in evolution, and this could even occur in one generation. I am guessing that this is the part of the film that the audience is supposed to suspend its belief about...
What about the basement laboratory? Smith's character used a fancy eyeglass-mounted video camera to record his experiments on various compounds to reverse the virus's symptoms in sewer rats. The writers got some things right here. Only "compound #6" worked; this was one of twenty he tried in this series, in what we assume was a long string of trials. This brings us to
Note #3: Only a small fraction of science experiments 'work.' Of note is that only one rat was tested with #6 before moving to human trials! I guess this paucity of pre-clinical data can be excused when civilization is at stake. While we are on the topic of animal experiments, the presentation of animal research in this film was well done. The rabid rats were clearly animated, so no beef could be made about living conditions for real rats (and the fact that they were injuring themselves on the cages). The cages, by the way, were appropriate for animal size and were not overcrowded. Smith's character didn't need to get IACUC approval for his work, but he
was mostly in compliance for many rules about animal care. Some notable lapses: no dedicated facility, interventions that were terminal, minimal personal protective equipment.
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The treatment of the bench science was appropriate. There were no unneeded CSI-styled eye-candy closeups of pipetting or tube shaking. (You know the shot: when one of the attractive lab techs flicks an Eppendorf tube up in front of his/her face instead of using the vortexer.) This workshop looked like a well stocked lab crossed with an intensive care unit. There were QPCR machines, vital signs monitors (just like those at the UW hospital!), and med supply carts along with an appropriate amount of clutter. Conveniently for the plot, there were also bullet-proof glass doors. Except for the dim lighting, this looked like a great place to do science.
In my opinion, the ethical land mine in this film was not the fact that some crazy scientist unleashed a deadly virus - that occurred off screen. I worried about the ethical use of human subjects. Smith's character has a wall packed with photos of zombies that he unsuccessfully cured of their zombieism. The viewer is asked to overlook the fact that these zombies have the potential to be fully human. At one point in the film, Smith's character reports that these creatures have lost all semblance of human nature. This is a fine trick to make it okay for experimenting on them. (That is how
some scientists justify animal research.) However, the observant audience member will note that the zombies have clear emotional responses to stimuli, exhibit abstract planning and operate in a social manner. One (the chief zombie) even seems to show an attachment to the zombie subject Smith's character is trying to cure.
Note #4: If a cure occurs only after sacrificing hundreds of zombie-humans, is the research ethical? Is exterminating the zombie way of life genocide?
Finally, over the course of the film, the protagonist shifts from a Christian to an atheist to an agnostic. First, he prays with his family before all Hell breaks loose. Later, he reasons that God would never permit such a catastrophe, therefore does not exist. The final resolution depends on a near-death and perhaps spiritual experience in which Smith's character adopts a perspective that things 'happen for a reason.' I did not appreciate (nor would my atheist readers) how his suicidal ideation occurred in the post-religion period, while the noble savior surfaced after reconsidering a religious perspective. Apart from that flaw, I was pleased that this portrayal of a scientist encompassed religious, agnostic and atheist perspectives, therefore illuminating
Note #5: Science can be done by individuals from diverse belief spectra.
In the end, my wife and I agreed that this was an entertaining movie and worth the $8 after a day of studying. The plot was creative enough to get me thinking about some interesting research ethics and science in society issues. Hopefully it got some others thinking as well.